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Vyzulta is a brand of latanoprostene bunod. What agents check before quoting it: how many 2026 Part D plans cover it, on which tier, with what restrictions and copays, by plan type, carrier and state.
In 2026, 4,226 of 5,496 Medicare Part D and Medicare Advantage drug plans (76.9%) list Vyzulta on their formulary, across 179 of 328 formularies. The most common placement is tier 4 (4,107 plans, 97.2% of those covering it). 8 of the covering plans require prior authorization (0.2%), 33 step therapy and 1,199 a quantity limit. Generic latanoprost is on 5,496 of 5,496 plans (100%).
322 covering plans charge a flat copay for a 30-day supply at a preferred retail pharmacy after the deductible — median $98.50, 52 of them $0; 3,904 charge coinsurance instead — median 30% of the drug's cost. Once a member's out-of-pocket drug spending reaches $2,100 in 2026, covered drugs cost $0 for the rest of the year.
2025: 4,132 of 5,631 plans covered it (73.4%); 2026: 4,226 of 5,496 (76.9%).
Of 4,368 plans offered in both years, 144 added it to the formulary and 39 dropped it.
Among plans covering it both years, 17 moved it to a higher tier and 7 to a lower one; 0 added prior authorization and 0 removed it.
Medicare Part D paid for 456,040 30-day fills of Vyzulta in 2024 for about 75,802 enrollees, at an average total cost of $281.24 per 30-day fill (CMS Part D Prescribers by Geography and Drug, national).
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Free tools for licensed insurance agents. Data from CMS public files; verify with plan documents before advising a client.
Counts are over every Medicare Advantage drug plan and stand-alone Part D plan in the CMS monthly formulary files, excluding employer plans. A plan counts as covering a drug when any strength or form of it is on the plan’s formulary; the tier, prior authorization, step therapy and quantity limit shown are the most favorable version on that formulary. Copays are for a 30-day supply at a preferred retail pharmacy after the deductible. This is a reference for licensed agents, not a plan recommendation; verify with the plan’s formulary before advising a client. Source: CMS Part D formulary files (release 09/16/2026). CMS formulary data.